WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:regulation of actin filament bundle assembly       ID:GO:0032231
C=44; O=2; E=0.08; R=25.58; rawP=0.0027; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:biological process       Name:activin receptor signaling pathway       ID:GO:0032924
C=32; O=2; E=0.06; R=35.17; rawP=0.0015; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:biological process       Name:macromolecule localization       ID:GO:0033036
C=1828; O=8; E=3.25; R=2.46; rawP=0.0115; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000109466 NA KLHL2 kelch-like 2, Mayven (Drosophila) 11275 ENSG00000109466
3  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020
4  ENSG00000175970 NA UNC119B unc-119 homolog B (C. elegans) 84747 ENSG00000175970
5  ENSG00000117859 NA OSBPL9 oxysterol binding protein-like 9 114883 ENSG00000117859
6  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
7  ENSG00000092871 NA RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 117584 ENSG00000092871
8  ENSG00000197324 NA LRP10 low density lipoprotein receptor-related protein 10 26020 ENSG00000197324


Database:biological process       Name:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II       ID:GO:0002504
C=96; O=2; E=0.17; R=11.72; rawP=0.0125; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000079616 NA KIF22 kinesin family member 22 3835 ENSG00000079616
2  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020


Database:biological process       Name:regulation of transforming growth factor beta receptor signaling pathway       ID:GO:0017015
C=91; O=2; E=0.16; R=12.37; rawP=0.0113; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:biological process       Name:negative regulation of osteoblast differentiation       ID:GO:0045668
C=35; O=2; E=0.06; R=32.15; rawP=0.0017; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:biological process       Name:regulation of actin cytoskeleton organization       ID:GO:0032956
C=174; O=3; E=0.31; R=9.70; rawP=0.0035; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000241685 NA ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 10552 ENSG00000241685
3  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:biological process       Name:positive regulation of Wnt receptor signaling pathway       ID:GO:0030177
C=72; O=2; E=0.13; R=15.63; rawP=0.0072; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:biological process       Name:antigen processing and presentation of exogenous peptide antigen via MHC class II       ID:GO:0019886
C=92; O=2; E=0.16; R=12.23; rawP=0.0115; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000079616 NA KIF22 kinesin family member 22 3835 ENSG00000079616
2  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020


Database:biological process       Name:regulation of osteoblast differentiation       ID:GO:0045667
C=97; O=2; E=0.17; R=11.60; rawP=0.0127; adjP=0.1819
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:molecular function       Name:ATPase binding       ID:GO:0051117
C=27; O=2; E=0.05; R=40.43; rawP=0.0011; adjP=0.0814
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
2  ENSG00000130770 NA ATPIF1 ATPase inhibitory factor 1 93974 ENSG00000130770


Database:molecular function       Name:SMAD binding       ID:GO:0046332
C=63; O=2; E=0.12; R=17.33; rawP=0.0059; adjP=0.1455
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:molecular function       Name:beta-catenin binding       ID:GO:0008013
C=63; O=2; E=0.12; R=17.33; rawP=0.0059; adjP=0.1455
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000151208 NA DLG5 discs, large homolog 5 (Drosophila) 9231 ENSG00000151208
2  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949


Database:molecular function       Name:lipid binding       ID:GO:0008289
C=742; O=5; E=1.36; R=3.68; rawP=0.0103; adjP=0.1905
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000225190 NA PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 9842 ENSG00000225190
2  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020
3  ENSG00000175970 NA UNC119B unc-119 homolog B (C. elegans) 84747 ENSG00000175970
4  ENSG00000117859 NA OSBPL9 oxysterol binding protein-like 9 114883 ENSG00000117859
5  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:molecular function       Name:chromatin binding       ID:GO:0003682
C=315; O=3; E=0.58; R=5.20; rawP=0.0194; adjP=0.2264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000140320 NA BAHD1 bromo adjacent homology domain containing 1 22893 ENSG00000140320
3  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:molecular function       Name:actin binding       ID:GO:0003779
C=356; O=3; E=0.65; R=4.60; rawP=0.0267; adjP=0.2264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109466 NA KLHL2 kelch-like 2, Mayven (Drosophila) 11275 ENSG00000109466
2  ENSG00000158195 NA WASF2 WAS protein family, member 2 10163 ENSG00000158195
3  ENSG00000241685 NA ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 10552 ENSG00000241685


Database:molecular function       Name:Ras GTPase activator activity       ID:GO:0005099
C=112; O=2; E=0.21; R=9.75; rawP=0.0178; adjP=0.2264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000167291 NA TBC1D16 TBC1 domain family, member 16 125058 ENSG00000167291
2  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:molecular function       Name:cytoskeletal protein binding       ID:GO:0008092
C=638; O=4; E=1.17; R=3.42; rawP=0.0278; adjP=0.2264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000151208 NA DLG5 discs, large homolog 5 (Drosophila) 9231 ENSG00000151208
2  ENSG00000109466 NA KLHL2 kelch-like 2, Mayven (Drosophila) 11275 ENSG00000109466
3  ENSG00000158195 NA WASF2 WAS protein family, member 2 10163 ENSG00000158195
4  ENSG00000241685 NA ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 10552 ENSG00000241685


Database:molecular function       Name:ubiquitin protein ligase binding       ID:GO:0031625
C=150; O=2; E=0.27; R=7.28; rawP=0.0306; adjP=0.2264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:molecular function       Name:small conjugating protein ligase binding       ID:GO:0044389
C=150; O=2; E=0.27; R=7.28; rawP=0.0306; adjP=0.2264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:cellular component       Name:Golgi cisterna membrane       ID:GO:0032580
C=72; O=2; E=0.12; R=16.92; rawP=0.0062; adjP=0.1229
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171302 NA CANT1 calcium activated nucleotidase 1 124583 ENSG00000171302
2  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:cellular component       Name:coated pit       ID:GO:0005905
C=57; O=2; E=0.09; R=21.37; rawP=0.0039; adjP=0.1229
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197324 NA LRP10 low density lipoprotein receptor-related protein 10 26020 ENSG00000197324
2  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020


Database:cellular component       Name:organelle subcompartment       ID:GO:0031984
C=90; O=2; E=0.15; R=13.53; rawP=0.0095; adjP=0.1229
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171302 NA CANT1 calcium activated nucleotidase 1 124583 ENSG00000171302
2  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:cellular component       Name:Golgi cisterna       ID:GO:0031985
C=87; O=2; E=0.14; R=14.00; rawP=0.0089; adjP=0.1229
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171302 NA CANT1 calcium activated nucleotidase 1 124583 ENSG00000171302
2  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:cellular component       Name:proton-transporting two-sector ATPase complex       ID:GO:0016469
C=49; O=2; E=0.08; R=24.86; rawP=0.0029; adjP=0.1229
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
2  ENSG00000130770 NA ATPIF1 ATPase inhibitory factor 1 93974 ENSG00000130770


Database:cellular component       Name:endocytic vesicle membrane       ID:GO:0030666
C=93; O=2; E=0.15; R=13.10; rawP=0.0101; adjP=0.1229
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
2  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020


Database:cellular component       Name:actin cytoskeleton       ID:GO:0015629
C=365; O=3; E=0.60; R=5.01; rawP=0.0214; adjP=0.1314
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109466 NA KLHL2 kelch-like 2, Mayven (Drosophila) 11275 ENSG00000109466
2  ENSG00000158195 NA WASF2 WAS protein family, member 2 10163 ENSG00000158195
3  ENSG00000241685 NA ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 10552 ENSG00000241685


Database:cellular component       Name:endomembrane system       ID:GO:0012505
C=1771; O=7; E=2.91; R=2.41; rawP=0.0216; adjP=0.1314
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197324 NA LRP10 low density lipoprotein receptor-related protein 10 26020 ENSG00000197324
2  ENSG00000171302 NA CANT1 calcium activated nucleotidase 1 124583 ENSG00000171302
3  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
4  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
5  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020
6  ENSG00000143418 NA CERS2 ceramide synthase 2 29956 ENSG00000143418
7  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635


Database:cellular component       Name:nuclear part       ID:GO:0044428
C=3071; O=10; E=5.04; R=1.98; rawP=0.0199; adjP=0.1314
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
2  ENSG00000176095 NA IP6K1 inositol hexakisphosphate kinase 1 9807 ENSG00000176095
3  ENSG00000129484 NA PARP2 poly (ADP-ribose) polymerase 2 10038 ENSG00000129484
4  ENSG00000159202 NA UBE2Z ubiquitin-conjugating enzyme E2Z 65264 ENSG00000159202
5  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
6  ENSG00000140320 NA BAHD1 bromo adjacent homology domain containing 1 22893 ENSG00000140320
7  ENSG00000197063 NA MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 4097 ENSG00000197063
8  ENSG00000143418 NA CERS2 ceramide synthase 2 29956 ENSG00000143418
9  ENSG00000174243 NA DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 9416 ENSG00000174243
10  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933


Database:cellular component       Name:intracellular organelle part       ID:GO:0044446
C=6725; O=17; E=11.04; R=1.54; rawP=0.0184; adjP=0.1314
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130770 NA ATPIF1 ATPase inhibitory factor 1 93974 ENSG00000130770
2  ENSG00000029639 NA TFB1M transcription factor B1, mitochondrial 51106 ENSG00000029639
3  ENSG00000175970 NA UNC119B unc-119 homolog B (C. elegans) 84747 ENSG00000175970
4  ENSG00000176095 NA IP6K1 inositol hexakisphosphate kinase 1 9807 ENSG00000176095
5  ENSG00000129484 NA PARP2 poly (ADP-ribose) polymerase 2 10038 ENSG00000129484
6  ENSG00000159202 NA UBE2Z ubiquitin-conjugating enzyme E2Z 65264 ENSG00000159202
7  ENSG00000033627 NA ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 535 ENSG00000033627
8  ENSG00000140320 NA BAHD1 bromo adjacent homology domain containing 1 22893 ENSG00000140320
9  ENSG00000197063 NA MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 4097 ENSG00000197063
10  ENSG00000174243 NA DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 9416 ENSG00000174243
11  ENSG00000157933 NA SKI v-ski sarcoma viral oncogene homolog (avian) 6497 ENSG00000157933
12  ENSG00000166949 NA SMAD3 SMAD family member 3 4088 ENSG00000166949
13  ENSG00000183020 NA AP2A2 adaptor-related protein complex 2, alpha 2 subunit 161 ENSG00000183020
14  ENSG00000186635 NA ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 116985 ENSG00000186635
15  ENSG00000171302 NA CANT1 calcium activated nucleotidase 1 124583 ENSG00000171302
16  ENSG00000079616 NA KIF22 kinesin family member 22 3835 ENSG00000079616
17  ENSG00000143418 NA CERS2 ceramide synthase 2 29956 ENSG00000143418




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).